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Target
Sentrin-specific protease 1
Ligand
BDBM94778
Substrate
n/a
IC50
41900±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94778
Synonyms:
2-Amino-7-phenylamino-4-pyridin-4-yl-4H-chromene-3-carbonitrile | 2-amino-7-anilino-4-(4-pyridyl)-4H-chromene-3-carbonitrile | 2-amino-7-anilino-4-pyridin-4-yl-4H-1-benzopyran-3-carbonitrile | 2-amino-7-anilino-4-pyridin-4-yl-4H-chromene-3-carbonitrile | 2-azanyl-7-phenylazanyl-4-pyridin-4-yl-4H-chromene-3-carbonitrile | MLS000527872 | SMR000120446 | cid_2961956
Type:
Small organic molecule
Emp. Form.:
C21H16N4O
Mol. Mass.:
340.3779
SMILES:
N=C1Oc2cc(Nc3ccccc3)ccc2C(C1C#N)c1ccncc1
Structure:
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