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Target
Sentrin-specific protease 1
Ligand
BDBM49568
Substrate
n/a
IC50
3280±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM49568
Synonyms:
4-chloro-2-[2-(2-quinolinyl)vinyl]phenyl acetate | MLS000583691 | SMR000199670 | [4-chloranyl-2-[(E)-2-quinolin-2-ylethenyl]phenyl] ethanoate | [4-chloro-2-[(E)-2-quinolin-2-ylethenyl]phenyl] acetate | acetic acid [4-chloro-2-[(E)-2-(2-quinolinyl)ethenyl]phenyl] ester | acetic acid [4-chloro-2-[(E)-2-(2-quinolyl)vinyl]phenyl] ester | cid_5739630
Type:
Small organic molecule
Emp. Form.:
C19H14ClNO2
Mol. Mass.:
323.773
SMILES:
CC(=O)Oc1ccc(Cl)cc1\C=C\c1ccc2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: