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Target
Sentrin-specific protease 1
Ligand
BDBM94867
Substrate
n/a
IC50
13100±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94867
Synonyms:
4-[6-bromanyl-3-[[2-(trifluoromethyl)phenyl]methyl]imidazo[1,2-a]pyridin-2-yl]benzenecarbonitrile | 4-[6-bromo-3-[2-(trifluoromethyl)benzyl]imidazo[1,2-a]pyridin-2-yl]benzonitrile | 4-[6-bromo-3-[[2-(trifluoromethyl)phenyl]methyl]-2-imidazo[1,2-a]pyridinyl]benzonitrile | 4-[6-bromo-3-[[2-(trifluoromethyl)phenyl]methyl]imidazo[1,2-a]pyridin-2-yl]benzonitrile | MLS003322126 | SMR002002141 | cid_51360605
Type:
Small organic molecule
Emp. Form.:
C22H13BrF3N3
Mol. Mass.:
456.258
SMILES:
FC(F)(F)c1ccccc1Cc1c(nc2ccc(Br)cn12)-c1ccc(cc1)C#N
Structure:
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