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Target
Sentrin-specific protease 1
Ligand
BDBM94873
Substrate
n/a
IC50
28300±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94873
Synonyms:
(2,6-dimethylphenyl)-[5,7-dimethyl-2-(3-pyridyl)imidazo[1,2-a]pyrimidin-3-yl]amine | MLS003589639 | N-(2,6-dimethylphenyl)-5,7-dimethyl-2-(3-pyridinyl)-3-imidazo[1,2-a]pyrimidinamine | N-(2,6-dimethylphenyl)-5,7-dimethyl-2-(pyridin-3-yl)imidazo[1,2-a]pyrimidin-3-amine | N-(2,6-dimethylphenyl)-5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyrimidin-3-amine | N-(2,6-dimethylphenyl)-5,7-dimethyl-2-pyridin-3-ylimidazo[1,2-a]pyrimidin-3-amine | SMR002249874 | cid_53301181
Type:
Small organic molecule
Emp. Form.:
C21H21N5
Mol. Mass.:
343.4249
SMILES:
Cc1cc(C)n2c(Nc3c(C)cccc3C)c(nc2n1)-c1cccnc1
Structure:
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