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TargetCytochrome P450 11B2 (CYP11B2)
LigandBDBM279780
Substrate/Competitorn/a
Meas. Tech.G-402 cell line assay
EC50 0.010±n/a nM
Citation Aebi, JAmrein, KEChen, JHornsperger, BKuhn, BLiu, YLi, DMaerki, HPMartin, REMayweg, ATan, XWu, JYu, J Spirodiamine derivatives as aldosterone synthase inhibitors US Patent US10035804 Publication Date 7/31/2018
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 11B2 (CYP11B2)
Name:Cytochrome P450 11B2 (CYP11B2)
Synonyms:Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:Protein
Mol. Mass.:57582.15
Organism:Homo sapiens (Human)
Description:P19099
Residue:503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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  Blast E-value cutoff:
BDBM279780
NameBDBM279780
Synonyms:US10035804, Example 51
TypeSmall organic molecule
Emp. Form.C25H25ClN6O2
Mol. Mass.476.958
SMILESCCn1cc(cn1)C(=O)N1CC2(C1)CN(C2)c1cncc(c1)N1[C@@H](C)c2cc(Cl)ccc2C1=O |r|
Structure
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