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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM94696
Substrate
n/a
IC50
>164727±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM94696
Synonyms:
3-(3-phenyl-1H-pyrazol-5-yl)-6-(2-pyridinyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 3-(3-phenyl-1H-pyrazol-5-yl)-6-(2-pyridyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 3-(3-phenyl-1H-pyrazol-5-yl)-6-pyridin-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | MLS000082990 | SMR000046928 | cid_665709
Type:
Small organic molecule
Emp. Form.:
C17H11N7S
Mol. Mass.:
345.381
SMILES:
c1c(n[nH]c1-c1nnc2sc(nn12)-c1ccccn1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: