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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM40968
Substrate
n/a
IC50
16692±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM40968
Synonyms:
7-methyl-N-piperonyl-furo[2,3-b]quinoline-2-carboxamide | MLS000091811 | N-(1,3-benzodioxol-5-ylmethyl)-7-methyl-2-furo[2,3-b]quinolinecarboxamide | N-(1,3-benzodioxol-5-ylmethyl)-7-methyl-furo[2,3-b]quinoline-2-carboxamide | N-(1,3-benzodioxol-5-ylmethyl)-7-methylfuro[2,3-b]quinoline-2-carboxamide | SMR000026358 | cid_3239723
Type:
Small organic molecule
Emp. Form.:
C21H16N2O4
Mol. Mass.:
360.3627
SMILES:
Cc1ccc2cc3cc(oc3nc2c1)C(=O)NCc1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: