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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95227
Substrate
n/a
IC50
>164706±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95227
Synonyms:
2-[2-(4-chlorophenyl)-2-oxidanylidene-ethyl]sulfanyl-7-methyl-pyrido[1,2-a][1,3,5]triazin-4-one | 2-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-7-methylpyrido[1,2-a][1,3,5]triazin-4-one | 2-[[2-(4-chlorophenyl)-2-keto-ethyl]thio]-7-methyl-pyrido[1,2-a][1,3,5]triazin-4-one | 2-[[2-(4-chlorophenyl)-2-oxoethyl]thio]-7-methyl-4-pyrido[1,2-a][1,3,5]triazinone | MLS001234936 | SMR000810930 | cid_7259093
Type:
Small organic molecule
Emp. Form.:
C16H12ClN3O2S
Mol. Mass.:
345.803
SMILES:
Cc1ccc2nc(SCC(=O)c3ccc(Cl)cc3)nc(=O)n2c1
Structure:
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