Reaction Details Report a problem with these data
Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95237
Substrate
n/a
IC50
69808±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95237
Synonyms:
5-ethoxy-3-methyl-2-benzofurancarboxylic acid [2-(3-methyl-1-piperidinyl)-2-oxoethyl] ester | 5-ethoxy-3-methyl-coumarilic acid [2-keto-2-(3-methylpiperidino)ethyl] ester | MLS002170389 | SMR001250706 | [2-(3-methylpiperidin-1-yl)-2-oxidanylidene-ethyl] 5-ethoxy-3-methyl-1-benzofuran-2-carboxylate | [2-(3-methylpiperidin-1-yl)-2-oxoethyl] 5-ethoxy-3-methyl-1-benzofuran-2-carboxylate | cid_16278897
Type:
Small organic molecule
Emp. Form.:
C20H25NO5
Mol. Mass.:
359.4162
SMILES:
CCOc1ccc2oc(C(=O)OCC(=O)N3CCCC(C)C3)c(C)c2c1
Structure:
Search PDB for entries with ligand similarity: