Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM405417
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
<1.000±n/a nM
Citation
 Gnamm, C; Oost, T; Peters, S; Rudolf, K Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent  USRE47493 Publication Date 7/9/2019 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM405417
Synonyms:
USRE47493, Example 39.5
Type:
Small organic molecule
Emp. Form.:
C26H21F3N4O4
Mol. Mass.:
510.4645
SMILES:
FC(F)(F)c1cccc(c1)N1C(=O)N(C(C2=C1CCCC2=O)c1ccc(cc1)C#N)C(=O)NC1COC1 |c:16|
Structure:
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