Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM405530
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
<1.000±n/a nM
Citation
 Gnamm, C; Oost, T; Peters, S; Rudolf, K Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent  USRE47493 Publication Date 7/9/2019 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM405530
Synonyms:
USRE47493, Example 75.3
Type:
Small organic molecule
Emp. Form.:
C27H27F3N4O5S
Mol. Mass.:
576.587
SMILES:
CC(C)NC(=O)N1[C@@H](C2=C(CCCC2=O)N(C1=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1S(C)(O)O)C#N |r,t:8|
Structure:
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