Reaction Details
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Report a problem with these dataTarget
Nuclear receptor subfamily 5 group A member 2
Ligand
BDBM95478
Substrate
n/a
IC50
8475±n/a nM
Citation
PubChem, PC Luminescence-based cell-based high throughput dose response assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) PubChem Bioassay (2013)[AID] More Info.:
Target
Name:
Nuclear receptor subfamily 5 group A member 2
Synonyms:
Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2
Type:
Nuclear Hormone Receptor
Mol. Mass.:
61341.37
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
541
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
Inhibitor
Name:
BDBM95478
Synonyms:
(2E)-1-(4-methoxyphenyl)-5,7-dimethyl-2-(2-oxidanylidenepropylidene)pyrido[2,3-d]pyrimidin-4-one | (2E)-1-(4-methoxyphenyl)-5,7-dimethyl-2-(2-oxopropylidene)-4-pyrido[2,3-d]pyrimidinone | (2E)-1-(4-methoxyphenyl)-5,7-dimethyl-2-(2-oxopropylidene)pyrido[2,3-d]pyrimidin-4-one | (2E)-2-acetonylidene-1-(4-methoxyphenyl)-5,7-dimethyl-pyrido[2,3-d]pyrimidin-4-one | 1-(4-methoxyphenyl)-5,7-dimethyl-2-(2-oxopropylidene)-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one | MLS000088720 | SMR000072738 | cid_5294436
Type:
Small organic molecule
Emp. Form.:
C19H19N3O3
Mol. Mass.:
337.3725
SMILES:
COc1ccc(cc1)N1C(NC(=O)c2c(C)cc(C)nc12)=CC(C)=O |w:21.24|
Structure:
