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Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95889
Substrate
n/a
EC50
5900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95889
Synonyms:
(E)-3-[(E)-1,3-benzodioxol-5-ylmethylideneamino]-N,4-dimethyl-1,3-thiazol-2-imine | (E)-3-[(E)-1,3-benzodioxol-5-ylmethylideneamino]-N,4-dimethyl-2-thiazolimine | MLS000096487 | SMR000062295 | cid_6903606 | methyl-[4-methyl-3-[(E)-piperonylideneamino]-4-thiazolin-2-ylidene]amine
Type:
Small organic molecule
Emp. Form.:
C13H13N3O2S
Mol. Mass.:
275.326
SMILES:
C\N=c1/scc(C)n1\N=C\c1ccc2OCOc2c1
Structure:
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