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Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM48110
Substrate
n/a
EC50
11600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM48110
Synonyms:
MLS000035103 | N-[6-(2-methylpropanoylamino)pyridin-3-yl]pyridine-2-carboxamide | N-[6-(isobutyrylamino)-3-pyridyl]picolinamide | N-[6-[(2-methyl-1-oxopropyl)amino]-3-pyridinyl]-2-pyridinecarboxamide | Pyridine-2-carboxylic acid (6-isobutyrylamino-pyridin-3-yl)-amide | SMR000005528 | cid_649501
Type:
Small organic molecule
Emp. Form.:
C15H16N4O2
Mol. Mass.:
284.3131
SMILES:
CC(C)C(=O)Nc1ccc(NC(=O)c2ccccn2)cn1
Structure:
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