Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM69834
Substrate
n/a
EC50
1030±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM69834
Synonyms:
1-[3-chloranyl-4-(4-chloranylphenoxy)phenyl]-6,6-dimethyl-1,3,5-triazine-2,4-diamine;hydrochloride | 1-[3-chloro-4-(4-chlorophenoxy)phenyl]-6,6-dimethyl-1,3,5-triazine-2,4-diamine;hydrochloride | 1-[3-chloro-4-(4-chlorophenoxy)phenyl]-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine | MLS001195109 | SMR000554425 | [4-amino-1-[3-chloro-4-(4-chlorophenoxy)phenyl]-6,6-dimethyl-s-triazin-2-yl]amine;hydrochloride | cid_2832015
Type:
Small organic molecule
Emp. Form.:
C17H17Cl2N5O
Mol. Mass.:
378.256
SMILES:
CC1(C)N=C(N)N=C(N)N1c1ccc(Oc2ccc(Cl)cc2)c(Cl)c1 |t:3,6|
Structure:
Search PDB for entries with ligand similarity: