Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM76617
Substrate
n/a
EC50
6800±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM76617
Synonyms:
2-[[(E)-3-(4-chlorophenyl)-3-keto-prop-1-enyl]amino]benzonitrile | 2-[[(E)-3-(4-chlorophenyl)-3-oxidanylidene-prop-1-enyl]amino]benzenecarbonitrile | 2-[[(E)-3-(4-chlorophenyl)-3-oxoprop-1-enyl]amino]benzonitrile | 2-{[3-(4-chlorophenyl)-3-oxo-1-propenyl]amino}benzonitrile | MLS001180487 | SMR000476404 | cid_1713605
Type:
Small organic molecule
Emp. Form.:
C16H11ClN2O
Mol. Mass.:
282.724
SMILES:
Clc1ccc(cc1)C(=O)CC=Nc1ccccc1C#N |w:11.12|
Structure:
Search PDB for entries with ligand similarity: