Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM96009
Substrate
n/a
EC50
5750±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM96009
Synonyms:
2-furancarboxylic acid [3-[(E)-[[(4-fluorophenyl)-oxomethyl]hydrazinylidene]methyl]phenyl] ester | 3-[2-(4-fluorobenzoyl)carbohydrazonoyl]phenyl 2-furoate | MLS000702159 | SMR000227086 | [3-[(E)-[(4-fluorobenzoyl)hydrazinylidene]methyl]phenyl] furan-2-carboxylate | [3-[(E)-[(4-fluorophenyl)carbonylhydrazinylidene]methyl]phenyl] furan-2-carboxylate | cid_56642938 | furan-2-carboxylic acid [3-[(E)-[(4-fluorobenzoyl)hydrazono]methyl]phenyl] ester
Type:
Small organic molecule
Emp. Form.:
C19H13FN2O4
Mol. Mass.:
352.3159
SMILES:
Fc1ccc(cc1)C(=O)N\N=C\c1cccc(OC(=O)c2ccco2)c1
Structure:
Search PDB for entries with ligand similarity: