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TargetFructose-1,6-bisphosphate aldolase (FBA)
LigandBDBM96191
Substrate/Competitorn/a
IC50>1110±n/a nM
Citation PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis PubChem Bioassay(2013)[AID]
More Info.:Get all data from this article
 
Fructose-1,6-bisphosphate aldolase (FBA)
Name:Fructose-1,6-bisphosphate aldolase (FBA)
Synonyms:FBP aldolase | FBPA | Fructose-1,6-bisphosphate aldolase | Fructose-bisphosphate aldolase | Probable fructose-bisphosphate aldolase Fba
Type:Protein
Mol. Mass.:36539.01
Organism:Mycobacterium tuberculosis (strain H37Rv)
Description:P9WQA3
Residue:344
Sequence:
MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFG
SGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKG
GNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKL
YTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGL
PADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLK
VDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTH
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  Blast E-value cutoff:
BDBM96191
NameBDBM96191
Synonyms:4-amino-5-N-(2,5-dimethylphenyl)-5-N-[2-oxo-2-(oxolan-2-ylmethylamino)-1-thiophen-2-ylethyl]-1,2-thiazole-3,5-dicarboxamide | 4-amino-N'-(2,5-dimethylphenyl)-N'-[2-keto-2-(tetrahydrofurfurylamino)-1-(2-thienyl)ethyl]isothiazole-3,5-dicarboxamide | 4-amino-N5-(2,5-dimethylphenyl)-N5-[2-oxo-2-(2-oxolanylmethylamino)-1-thiophen-2-ylethyl]isothiazole-3,5-dicarboxamide | 4-azanyl-N5-(2,5-dimethylphenyl)-N5-[2-oxidanylidene-2-(oxolan-2-ylmethylamino)-1-thiophen-2-yl-ethyl]-1,2-thiazole-3,5-dicarboxamide | MLS000710874 | SMR000280641 | cid_3173326
TypeSmall organic molecule
Emp. Form.C24H27N5O4S2
Mol. Mass.513.632
SMILESCc1ccc(C)c(c1)N(C(C(=O)NCC1CCCO1)c1cccs1)C(=O)c1snc(C(N)=O)c1N
Structure
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