Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM87378
Substrate
n/a
IC50
>118589±n/a nM
Citation
 PubChem, PC Absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2013)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM87378
Synonyms:
MLS002702369 | N-[1-[(carbamothioylhydrazinylidene)methyl]-4-isoquinolinyl]-N-ethylacetamide | N-[1-[(carbamothioylhydrazinylidene)methyl]isoquinolin-4-yl]-N-ethyl-ethanamide | N-[1-[(carbamothioylhydrazinylidene)methyl]isoquinolin-4-yl]-N-ethylacetamide | N-ethyl-N-[1-[(thiocarbamoylhydrazono)methyl]-4-isoquinolyl]acetamide | SMR001565931 | cid_3005256
Type:
Small organic molecule
Emp. Form.:
C15H17N5OS
Mol. Mass.:
315.393
SMILES:
CCN(C(C)=O)c1cnc(C=NNC(N)=S)c2ccccc12 |w:11.11|
Structure:
Search PDB for entries with ligand similarity: