Reaction Details
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RecBCD enzyme subunit RecD
Ligand
BDBM96304
Substrate
n/a
IC50
41156±n/a nM
Citation
PubChem, PC Absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2013)[AID] More Info.:
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
Inhibitor
Name:
BDBM96304
Synonyms:
4H-Imidazo[4,5-d]-v-triazin-4-one, 3,7-dihydro-7-.beta.-D-ribofuranosyl- | 7-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)-1H-imidazo[4,5-d]triazin-4-one | 7-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-1H-imidazo[4,5-d]triazin-4-one | 7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-imidazo[4,5-d]triazin-4-one | 7-[5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1H-imidazo[4,5-d][1,2,3]triazin-4-one | MLS003389439 | SMR002049092 | cid_292763
Type:
Small organic molecule
Emp. Form.:
C9H11N5O5
Mol. Mass.:
269.2141
SMILES:
OCC1OC(C(O)C1O)n1cnc2c1nn[nH]c2=O
Structure:
