Reaction Details
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Report a problem with these dataTarget
T cell receptor alpha variable 4
Ligand
BDBM96406
Substrate
n/a
IC50
10735±n/a nM
Citation
PubChem, PC Fluorescence-based biochemical primary high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe PubChem Bioassay (2013)[AID] More Info.:
Target
Name:
T cell receptor alpha variable 4
Synonyms:
TCRAV4S1 | TRAV4 | TVA4_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12216.28
Organism:
Homo sapiens (Human)
Description:
A0A0B4J268
Residue:
109
Sequence:
MRQVARVIVFLTLSTLSLAKTTQPISMDSYEGQEVNITCSHNNIATNDYITWYQQFPSQGPRFIIQGYKTKVTNEVASLFIPADRKSSTLSLPRVSLSDTAVYYCLVGD
Inhibitor
Name:
BDBM96406
Synonyms:
4-[(3,4-dichlorophenyl)carbamoylamino]-2-ethyl-1H-1,5-benzodiazepine-3-carboxylic acid ethyl ester | 4-[[(3,4-dichloroanilino)-oxomethyl]amino]-2-ethyl-1H-1,5-benzodiazepine-3-carboxylic acid ethyl ester | MLS002635616 | SMR000150865 | cid_5176394 | ethyl 4-[(3,4-dichlorophenyl)carbamoylamino]-2-ethyl-1H-1,5-benzodiazepine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H20Cl2N4O3
Mol. Mass.:
447.314
SMILES:
CCOC(=O)C1C(CC)=Nc2ccccc2N=C1NC(=O)Nc1ccc(Cl)c(Cl)c1 |c:8,17|
Structure:
