Target
Endothelin-converting enzyme 1
Ligand
BDBM50171626
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
10±0.0 nM
Citation
 Brands, MErgüden, JKErgüden, KHeimbach, DKrahn, TSchröder, CSchröder, SStasch, JPTsujishita, HWeigand, SYoshida, NH Selective indole-based ECE inhibitors: synthesis and pharmacological evaluation. ChemMedChem 1:96-105 (2006) [PubMed]  Article 
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE)
Type:
Protein
Mol. Mass.:
86126.89
Organism:
Rattus norvegicus (Rat)
Description:
P42893
Residue:
762
Sequence:
MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
  
Inhibitor
Name:
BDBM50171626
Synonyms:
5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-1H-indole-2-carboxylic acid [3-(4-sulfamoyl-phenylcarbamoyl)-phenyl]-amide | CHEMBL381643 | ECE Inhibitor, 11
Type:
Small organic molecule
Emp. Form.:
C35H34FN5O5S
Mol. Mass.:
655.738
SMILES:
CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccccc3F)c(cc2c1)C(=O)Nc1cccc(c1)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Structure:
Search PDB for entries with ligand similarity: