Reaction Details Report a problem with these data
Target
Urokinase plasminogen activator surface receptor
Ligand
BDBM98603
Substrate
n/a
Meas. Tech.
Enzyme Assay
Temperature
297.15±0 K
Ki
110±0.0 nM
Citation
 Stuerzebecher, J; Steinmetzer, T; Schweinitz, A Urokinase inhibitors, production and use thereof US Patent  US8476306 Publication Date 7/2/2013 
Target
Name:
Urokinase plasminogen activator surface receptor
Synonyms:
CD87 | Plasminogen activator urokinase | Plaur | U-PAR | UPAR | UPAR_RAT | URKR
Type:
Protein
Mol. Mass.:
35754.96
Organism:
Rattus norvegicus
Description:
P49616
Residue:
328
Sequence:
MGLLRRRLLLLVVVVTTCVPASQGLRCIQCESNQDCLVEECALGQDLCRTTVLREWEDAEELEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCNRPRPGARGRPFPRGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSVKDEPYTKGCGSLPGCPGTAGFHSNQTFHFLKCCNFTQCNGGPVLDLQSLPPNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLGNRSYTVRGCATASWCQGSHVADSFQTHVNLSISCCNGSGCNRPTGGAPGPGPAHLILIASLLLTLRLWGIPLWT
  
Inhibitor
Name:
BDBM98603
Synonyms:
3-amino-N-[4-[[(2S)-2-[[(2R)-2-(benzylsulfonylamino)-3-hydroxy-propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]phenyl]-4-methoxy-benzamide | US8476306, 12
Type:
Small organic molecule
Emp. Form.:
C24H29N7O5S
Mol. Mass.:
527.596
SMILES:
NC(=N)c1ccc(CNC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CO)NS(=O)(=O)Cc2ccccc2)cc1
Structure:
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