Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM100191
Substrate
n/a
EC50
8144±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100191
Synonyms:
1-[1-(1H-benzimidazol-2-yl)ethyl]-3-(2-thienyl)quinoxalin-2-one | 1-[1-(1H-benzimidazol-2-yl)ethyl]-3-thiophen-2-yl-2-quinoxalinone | 1-[1-(1H-benzimidazol-2-yl)ethyl]-3-thiophen-2-yl-quinoxalin-2-one | 1-[1-(1H-benzimidazol-2-yl)ethyl]-3-thiophen-2-ylquinoxalin-2-one | MLS003675329 | SMR001921250 | cid_53383497
Type:
Small organic molecule
Emp. Form.:
C21H16N4OS
Mol. Mass.:
372.443
SMILES:
CC(c1nc2ccccc2[nH]1)n1c2ccccc2nc(-c2cccs2)c1=O
Structure:
Search PDB for entries with ligand similarity: