Target
Monoglyceride lipase
Ligand
BDBM280589
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling (Human)
Temperature
298.15±n/a K
IC50
<100±n/a nM
Comments
extracted
Citation
 Cisar, JSGrice, CAJones, TKWeber, ODBuzard, DJShaghafi, MB Spirocycle compounds and methods of making and using same US Patent  US10030020 Publication Date 7/24/2018 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM280589
Synonyms:
US10030020, Example 134 | US10781211, Example 134
Type:
Small organic molecule
Emp. Form.:
C24H28F9N3O2
Mol. Mass.:
561.4836
SMILES:
FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(c(c2)N2CCCC2)C(F)(F)F)CC1)C(F)(F)F
Structure:
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