Reaction Details
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Pro-glucagon
Ligand
BDBM100823
Substrate
n/a
Meas. Tech.
Glucagon SPA Assay
pH
7.4±0
Ki
93.2±0.0 nM
Citation
Aspnes, GE; Didiuk, MT; Filipski, KJ; Guzman-Perez, A; Lee, EC; Pfefferkorn, JA; Stevens, BD; Tu, MM Glucagon receptor modulators US Patent US8507533 Publication Date 8/13/2013 More Info.:
Target
Name:
Pro-glucagon
Synonyms:
GCG | GLUC_HUMAN | Glucagon | Glucagon receptor (GCGR)
Type:
Enzyme
Mol. Mass.:
20907.95
Organism:
Homo sapiens (Human)
Description:
P01275
Residue:
180
Sequence:
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
Inhibitor
Name:
BDBM100823
Synonyms:
US8507533, 130 | US8507533, 369
Type:
Small organic molecule
Emp. Form.:
C25H28ClN3O4
Mol. Mass.:
469.961
SMILES:
CCCC(Oc1cc(C)c(c(C)c1)-n1cc(Cl)cn1)c1ccc(cc1)C(=O)NCCC(O)=O
Structure:
