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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM100924
Substrate
n/a
Meas. Tech.
Uptake Inhibition Assay
Temperature
273.15±n/a K
IC50
16.5±n/a nM
Citation
 Kolczewski, S; Pinard, E Tetrahydro-pyran derivatives US Patent  US8524909 Publication Date 9/3/2013 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
Glycine transporter 1b | SC6A9_BOVIN | SLC6A9
Type:
Protein
Mol. Mass.:
71324.09
Organism:
Bos taurus (Bovine)
Description:
Q28039
Residue:
638
Sequence:
MAAAQGPVAPSSLEQNGAVPSEATKKDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTPVLPWTYCNNPWNTPDCMSVLDNPNITNGSQPPALPGNVSQALNQTLKRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFIRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLVTMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVIISCIMCVSIMYIYGHQNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILIFSVIQYQPITYNQYQYPSWRVRIGFLMALSSVICIPLYALFQFCRTDGDTLLHRLKNATKPSRDWGPALLEHRTRRYAPTTTPSPEDGLEVQPLHPDKAQIPMVGSNGSSRFQDSRI
  
Inhibitor
Name:
BDBM100924
Synonyms:
US8524909, 113 | US8524909, 42 | US8524909, 9
Type:
Small organic molecule
Emp. Form.:
C19H22F6N2O2S
Mol. Mass.:
456.446
SMILES:
CSc1cc(cc(c1C(=O)N[C@@H]1COCC[C@H]1N1CCCC1)C(F)(F)F)C(F)(F)F |r|
Structure:
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