Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM101470
Substrate
n/a
Meas. Tech.
Enzyme Inhbition Assay
IC50
0.056±n/a nM
Citation
 Banner, D; Grether, U; Haap, W; Kuehne, H; Mauser, H; Plancher, J Pyrrolidine derivatives US Patent  US8524710 Publication Date 9/3/2013 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM101470
Synonyms:
US8524710, 48
Type:
Small organic molecule
Emp. Form.:
C23H24ClF3N6O2S
Mol. Mass.:
540.989
SMILES:
FC(F)(F)c1cc(nc(n1)C#N)N1CC[C@@H](C1)S(=O)(=O)c1ccc(cc1Cl)N1CCN(CC1)C1CC1 |r|
Structure:
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