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Target
Serine/threonine-protein kinase PAK 4
Ligand
BDBM101549
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Ki
8.3±n/a nM
EC50
<3.9±0.0 nM
Citation
 Zhang, J; Guo, C; Bouzida, D; Dong, L; Li, H; Marakovits, JT; Yang, A; Hong, Y Pyrrolopyrazoles, potent kinase inhibitors US Patent  US8530652 Publication Date 9/10/2013 
Target
Name:
Serine/threonine-protein kinase PAK 4
Synonyms:
KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:
Protein
Mol. Mass.:
64098.01
Organism:
Homo sapiens (Human)
Description:
O96013
Residue:
591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
  
Inhibitor
Name:
BDBM101549
Synonyms:
US8530494, 109 | US8530652, 128 | US8530652, 76
Type:
Small organic molecule
Emp. Form.:
C23H26F3N7O2
Mol. Mass.:
489.4934
SMILES:
CN(C)C[C@@H](OC(=O)N1Cc2c(Nc3ccnc(n3)C(F)(F)F)[nH]nc2C1(C)C)c1ccccc1 |r|
Structure:
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