Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM102224
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.5±0
Kd
36±n/a nM
Citation
 Badiger, S; Behnke, D; Betschart, C; Chaudhari, V; Cotesta, S; Hinrichs, JH; Ofner, S; Pandit, C; Wagner, J Diaza-spiro[5.5]undecanes US Patent  US8530648 Publication Date 9/10/2013 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM102224
Synonyms:
US8530648, 161
Type:
Small organic molecule
Emp. Form.:
C27H27N5O2
Mol. Mass.:
453.5356
SMILES:
O=C1N(Cc2ncoc2-c2ccccc2)CCCC11CCN(CC1)c1cnc2ccccc2n1
Structure:
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