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Target
Fibroblast growth factor receptor 3
Ligand
BDBM102508
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
16±0.0 nM
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8536175 Publication Date 9/17/2013 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM102508
Synonyms:
US8536175, 20
Type:
Small organic molecule
Emp. Form.:
C26H27Cl2N7O3
Mol. Mass.:
556.444
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12 |(11.06,-2.67,;9.52,-2.67,;8.75,-1.33,;9.52,,;8.75,1.33,;9.52,2.67,;8.75,4,;7.21,1.33,;6.44,2.67,;6.44,,;7.21,-1.33,;6.44,-2.67,;4.9,,;4.13,1.33,;2.59,1.33,;1.82,,;.28,,;-.49,1.33,;-.49,-1.33,;-2.03,-1.33,;-2.93,-.09,;-4.4,-.56,;-4.4,-2.1,;-5.73,-2.87,;-7.06,-2.1,;-7.06,-.56,;-8.4,.21,;-9.73,-.56,;-11.06,.21,;-9.73,-2.1,;-8.4,-2.87,;-2.93,-2.58,;2.59,-1.33,;1.82,-2.67,;2.59,-4,;4.13,-4,;4.9,-2.67,;4.13,-1.33,)|
Structure:
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