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Target
Sentrin-specific protease 2
Ligand
BDBM103833
Substrate
SUMO2
Meas. Tech.
SUMO Cleavage Assay
pH
7.4±0
IC50
4.106e+4± 5.2e+3 nM
Citation
 Madu, IG; Namanja, AT; Su, Y; Wong, S; Li, YJ; Chen, Y Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors. ACS Chem Biol 8:1435-41 (2013) [PubMed]  Article 
Target
Name:
Sentrin-specific protease 2
Synonyms:
KIAA1331 | SENP2 | SENP2_HUMAN | Sentrin-specific protease 2 (SENP2)
Type:
Protein
Mol. Mass.:
67890.62
Organism:
Homo sapiens (Human)
Description:
Q9HC62
Residue:
589
Sequence:
MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
  
Inhibitor
Name:
BDBM103833
Synonyms:
SPI-08 | US11041859, Code SPI-08 | US9791447, Compound SPI-08
Type:
Small organic molecule
Emp. Form.:
C16H12N3O3S
Mol. Mass.:
326.35
SMILES:
Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Small ubiquitin-related modifier 2
Synonyms:
SMT3B | SMT3H2 | SUMO2 | SUMO2_HUMAN | Small ubiquitin-related modifier 2
Type:
Protein
Mol. Mass.:
10869.09
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
95
Sequence:
MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY