Target
Complement factor D
Ligand
BDBM109056
Substrate
n/a
Meas. Tech.
Human Factor D Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<1000±n/a nM
Comments
extracted
Citation
 Wiles, JAWang, QGadhachanda, VRPais, GHashimoto, AChen, DWang, XAgarwal, ADeshpande, MPhadke, AS Amide compounds for treatment of complement mediated disorders US Patent  US9695205 Publication Date 7/4/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM109056
Synonyms:
US9695205, 2
Type:
Small organic molecule
Emp. Form.:
C27H26ClF2N9O4
Mol. Mass.:
614.003
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(NC(=O)NCc3nn[nH]n3)cc12 |r|
Structure:
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