Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Ligand
BDBM103585
Substrate
n/a
IC50
450±75 nM
Citation
 Kawaguchi, MOkabe, TOkudaira, SNishimasu, HIshitani, RKojima, HNureki, OAoki, JNagano, T Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe. ACS Chem Biol 8:1713-21 (2013) [PubMed]  Article 
Target
Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Synonyms:
Autotaxin | Autotaxin (mATX) | ENPP2_MOUSE | Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | Npps2 | Pdnp2
Type:
PROTEIN
Mol. Mass.:
98896.47
Organism:
Mus musculus
Description:
n/a
Residue:
862
Sequence:
MARQGCFGSYQVISLFTFAIGVNLCLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
  
Inhibitor
Name:
BDBM103585
Synonyms:
ATX inhibitor 10 analogue 15
Type:
Small organic molecule
Emp. Form.:
C22H22Cl2N4OS
Mol. Mass.:
461.407
SMILES:
Clc1ccc(\C=C2/SC(=NC2=O)N2CCN(CCCc3ccccn3)CC2)cc1Cl |c:8|
Structure:
Search PDB for entries with ligand similarity: