Reaction Details Report a problem with these data
Target
DNA polymerase beta
Ligand
BDBM104069
Substrate
n/a
Meas. Tech.
DNA Pol β PEX Assay
pH
7.9±n/a
IC50
>5.0e+4±n/a nM
Comments
extracted
Citation
 Strittmatter, T; Brockmann, A; Pott, M; Hantusch, A; Brunner, T; Marx, A Expanding the Scope of Human DNA Polymerase ¿ and ß Inhibitors. ACS Chem Biol 9:282-90 (2014) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM104069
Synonyms:
(Z)-5-(3-Nitro-4-(p-tolylthio)benzylidene)thiazolidine-2,4-dione 3 | DNA polymerase inhibitor 3
Type:
Small organic molecule
Emp. Form.:
C17H12N2O4S2
Mol. Mass.:
372.418
SMILES:
Cc1ccc(Sc2ccc(C=C3SC(O)=NC3=O)cc2[N+]([O-])=O)cc1 |w:10.9,c:14|
Structure:
Search PDB for entries with ligand similarity: