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Target
DNA polymerase lambda
Ligand
BDBM104093
Substrate
n/a
Meas. Tech.
DNA Pol λ PEX Assay
pH
7.5±n/a
IC50
4.0e+3±n/a nM
Comments
extracted
Citation
 Strittmatter, T; Brockmann, A; Pott, M; Hantusch, A; Brunner, T; Marx, A Expanding the Scope of Human DNA Polymerase ¿ and ß Inhibitors. ACS Chem Biol 9:282-90 (2014) [PubMed]  Article 
Target
Name:
DNA polymerase lambda
Synonyms:
DNA polymerase lambda (Pol λ) | DPOLL_HUMAN | POLL
Type:
Protein
Mol. Mass.:
63493.10
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
575
Sequence:
MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPAQGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQDASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEGDCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
  
Inhibitor
Name:
BDBM104093
Synonyms:
(Z)-5-(3-Bromo-4-((3-fluoro-4-methylphenyl)thio)benzylidene)-2- thioxothiazolidin-4-one 27 | DNA polymerase inhibitor 27
Type:
Small organic molecule
Emp. Form.:
C17H11BrFNOS3
Mol. Mass.:
440.373
SMILES:
Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2Br)cc1F |w:10.9,c:14|
Structure:
Search PDB for entries with ligand similarity: