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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM104169
Substrate
n/a
Meas. Tech.
PIM-3 Enzyme Assay
pH
7.4±0
Temperature
295.15±0 K
IC50
4±0.0 nM
Citation
 Allen, S; Celeste, LL; Davis, TG; DeLisle, RK; Greschuk, JM; Gross, SD; Hicken, EJ; Jackson, LJ; Kallan, NC; Lyssikatos, JP; Marmsater, FP; Munson, MC; Pheneger, J; Rast, B; Robinson, JE; Schlachter, ST; Topalov, GT; Wright, AD; Zhao, Q Triazolopyridine compounds as PIM kinase inhibitors US Patent  US8575145 Publication Date 11/5/2013 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
Kid1 | PIM3_RAT | Pim3
Type:
Protein
Mol. Mass.:
35997.25
Organism:
Rattus norvegicus (Rat)
Description:
O70444
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKVYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGMAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWMLGTEGSVPENCDLRLCALDTDDGASTTSSSESL
  
Inhibitor
Name:
BDBM104169
Synonyms:
US8575145, 46/47/48/49/50 | US8575145, 77 | US8575145, 78 | US8575145, 79 | US8575145, 80
Type:
Small organic molecule
Emp. Form.:
C21H20FN5O
Mol. Mass.:
377.4148
SMILES:
FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12
Structure:
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