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Target
Mitogen-activated protein kinase 9
Ligand
BDBM104974
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
253.5±n/a nM
Citation
 Buettelmann, B; Goyal, B; Palmer, WS JNK modulators US Patent  US8569306 Publication Date 10/29/2013 
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM104974
Synonyms:
US8569306, 11
Type:
Small organic molecule
Emp. Form.:
C17H19N5O
Mol. Mass.:
309.3657
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-c1cnc2ccccn12 |r,wU:4.7,wD:1.0,(-3.19,-4.62,;-3.19,-3.08,;-1.85,-2.31,;-1.85,-.77,;-3.19,,;-4.52,-.77,;-4.52,-2.31,;-3.19,1.54,;-1.85,2.31,;-1.85,3.85,;-.52,4.62,;.82,3.85,;.82,2.31,;-.52,1.54,;2.15,1.54,;3.61,2.02,;4.52,.77,;3.61,-.48,;3.93,-1.98,;2.79,-3.01,;1.32,-2.54,;1,-1.03,;2.15,,)|
Structure:
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