Target
Neutrophil elastase
Ligand
BDBM105231
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
pH
7.4±0
Temperature
310.15±0 K
IC50
4±0.0 nM
Citation
 Von Nussbaum, FKarthaus, DDelbeck, MLi, VMMeibom, DLustig, K 1,4-diaryl-pyrimidopyridazine-2,5-diones and their use US Patent  US8580800 Publication Date 11/12/2013 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM105231
Synonyms:
US8580800, 23
Type:
Small organic molecule
Emp. Form.:
C25H23F3N6O3
Mol. Mass.:
512.4837
SMILES:
CN(C)C(=O)CN1[C@@H](C2=C(CN(C)NC2=O)N(C1=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1)C#N |r,t:8|
Structure:
Search PDB for entries with ligand similarity: