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Target15-Lipoxygenase-2 (15-LOX-2)
LigandBDBM106776
Substrate/Competitorn/a
Meas. Tech.IC50 Assay
pH7.5±0
Temperature296.15±0 K
IC50>3.0e+4± 0 nM
Citation Mascayano, CEspinosa, VSepúlveda-Boza, SSepúlveda-Boza, EKPerry, S In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases. Chem Biol Drug Des82:317-25 (2013) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
15-Lipoxygenase-2 (15-LOX-2)
Name:15-Lipoxygenase-2 (15-LOX-2)
Synonyms:15-LOX-2 | 15-Lipo-oxygenase type 2 (15-LOX-2) | 15-lipoxygenase 2 | Arachidonate 15-lipoxygenase type II | Arachidonate 15-lipoxygenase, type II | Arachidonate 15-lipoxygenase-2 | Epithelial 15-lipoxygenase-2
Type:Protein
Mol. Mass.:75850.40
Organism:Homo sapiens (Human)
Description:n/a
Residue:676
Sequence:
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPED
VGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQE
GTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAK
NANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFAS
QFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT
NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWV
RNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELL
IVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQI
WGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQ
YVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT
CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVL
PYTYLDPPLIENSVSI
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  Blast E-value cutoff:
BDBM106776
NameBDBM106776
Synonyms:3‐(3‐chlorophenyl)‐6,7‐dihydroxy‐4H‐chromen‐4‐one | 6,7-Dihydroxy-3′-chloro-isoflavone (1c) | IR-8
TypeSmall organic molecule
Emp. Form.C15H9ClO4
Mol. Mass.288.683
SMILESOc1cc2occ(-c3cccc(Cl)c3)c(=O)c2cc1O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a