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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM106793
Substrate
n/a
Meas. Tech.
PTP activity assay
pH
6±n/a
Temperature
310.15±n/a K
IC50
4.41e+4±n/a nM
Comments
extracted
Citation
 Ma, Y; Sun, SX; Cheng, XC; Wang, SQ; Dong, WL; Wang, RL; Xu, WR Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase. Chem Biol Drug Des 82:595-602 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM106793
Synonyms:
(5Z)‐5‐{[3‐(2‐ phenylethoxy)phenyl]methylidene}imidazolidine‐2,4‐ dione (comp#e)
Type:
Small organic molecule
Emp. Form.:
C18H16N2O3
Mol. Mass.:
308.3312
SMILES:
O=C1NC(=O)\C(N1)=C\c1cccc(OCCc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: