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Target
Cyclin-dependent kinase 2
Ligand
BDBM106965
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
9e+1±n/a nM
Citation
 Sheldrake, PW; Atrash, B; Green, S; McDonald, E; Frame, S Trisubstituted purine derivatives US Patent  US8592581 Publication Date 11/26/2013 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM106965
Synonyms:
US8592581, 16
Type:
Small organic molecule
Emp. Form.:
C19H24F3N7O
Mol. Mass.:
423.4354
SMILES:
CCC(Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(F)(F)F
Structure:
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