Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281660
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
170±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281660
Synonyms:
Cis-2-(-3-(2′-fluoro-5′-phenoxy-[1,1′-biphenyl]-4-yl)cyclobutoxy)acetic acid | US10023519, Example 1
Type:
Small organic molecule
Emp. Form.:
C24H21FO4
Mol. Mass.:
392.4195
SMILES:
OC(=O)CO[C@H]1C[C@H](C1)c1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F |r,wD:7.9,5.4,(8.02,2,;7.25,3.33,;8.02,4.67,;5.71,3.33,;4.94,2,;3.4,2,;2.31,3.09,;1.22,2,;2.31,.91,;-.32,2,;-1.09,.67,;-2.63,.67,;-3.4,2,;-2.63,3.33,;-1.09,3.33,;-4.94,2,;-5.71,.67,;-7.25,.67,;-8.02,-.67,;-7.25,-2,;-8.02,-3.33,;-7.25,-4.67,;-5.71,-4.67,;-4.94,-3.33,;-5.71,-2,;-8.02,2,;-7.25,3.33,;-5.71,3.33,;-4.94,4.67,)|
Structure:
