Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281699
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
9270±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281699
Synonyms:
2-(3-(2′-Fluoro-5′-phenoxy-[1,1′-biphenyl]-4-yl)cyclobutyl)cyclopropanecarboxylic acid | US10023519, Example 40
Type:
Small organic molecule
Emp. Form.:
C26H23FO3
Mol. Mass.:
402.4574
SMILES:
OC(=O)[C@H]1CC1[C@H]1C[C@H](C1)c1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F |r,wU:3.2,wD:8.11,6.6,(8.28,5.55,;6.94,6.32,;6.94,7.86,;5.61,5.55,;6.94,4.78,;5.61,4.01,;4.28,3.24,;2.79,3.64,;2.39,2.15,;3.88,1.75,;1.06,1.38,;1.06,-.16,;-.28,-.93,;-1.61,-.16,;-1.61,1.38,;-.28,2.15,;-2.94,-.93,;-2.94,-2.47,;-4.28,-3.24,;-4.28,-4.78,;-5.61,-5.55,;-6.94,-4.78,;-8.28,-5.55,;-8.28,-7.09,;-6.94,-7.86,;-5.61,-7.09,;-5.61,-2.47,;-5.61,-.93,;-4.28,-.16,;-4.28,1.38,)|
Structure:
