Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281718
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
520±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281718
Synonyms:
2-(3-(Cis-3-(3-phenoxybenzyloxy)cyclobutyl)propoxy)acetic acid | US10023519, Example 59
Type:
Small organic molecule
Emp. Form.:
C22H26O5
Mol. Mass.:
370.4388
SMILES:
OC(=O)COCCC[C@H]1C[C@H](C1)OCc1cccc(Oc2ccccc2)c1 |r,wU:10.12,8.7,(11.61,2.47,;10.28,1.7,;10.28,.16,;8.95,2.47,;7.61,1.7,;6.28,2.47,;4.94,1.7,;3.61,2.47,;2.28,1.7,;1.88,.21,;.39,.61,;.79,2.1,;-.94,-.16,;-2.28,.61,;-3.61,-.16,;-3.61,-1.7,;-4.94,-2.47,;-6.28,-1.7,;-6.28,-.16,;-7.61,.61,;-8.95,-.16,;-8.95,-1.7,;-10.28,-2.47,;-11.61,-1.7,;-11.61,-.16,;-10.28,.61,;-4.94,.61,)|
Structure:
