Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Probable G-protein coupled receptor 160
Ligand
BDBM281721
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
570±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281721
Synonyms:
3-(3-(Cis-1-methyl-3-(3-phenoxyphenyl)cyclobutyl)propoxy)propanoic acid | US10023519, Example 62
Type:
Small organic molecule
Emp. Form.:
C23H28O4
Mol. Mass.:
368.466
SMILES:
C[C@@]1(CCCOCCC(O)=O)C[C@@H](C1)c1cccc(Oc2ccccc2)c1 |r,wU:12.14,1.1,wD:1.0,(-.49,2.26,;.28,.93,;1.61,1.7,;2.94,.93,;4.28,1.7,;5.61,.93,;6.94,1.7,;8.28,.93,;9.61,1.7,;10.95,.93,;9.61,3.24,;-1.21,1.33,;-1.61,-.16,;-.12,-.56,;-2.94,-.93,;-2.94,-2.47,;-4.28,-3.24,;-5.61,-2.47,;-5.61,-.93,;-6.94,-.16,;-8.28,-.93,;-9.61,-.16,;-10.95,-.93,;-10.95,-2.47,;-9.61,-3.24,;-8.28,-2.47,;-4.28,-.16,)|
Structure:
