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Target
Kininogen-1
Ligand
BDBM107156
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
IC50
0.6±n/a nM
Citation
 Aebi, J; Binggeli, A; Hertel, C; Konkar, AA; Kuehne, H; Kuhn, B; Maerki, HP; Wang, H Aryl-benzocycloalkyl amide derivatives US Patent  US8592426 Publication Date 11/26/2013 
Target
Name:
Kininogen-1
Synonyms:
BDK | Bradykinin-1 Receptor | KNG | KNG1 | KNG1_HUMAN
Type:
Enzyme
Mol. Mass.:
71962.11
Organism:
Homo sapiens (Human)
Description:
P01042
Residue:
644
Sequence:
MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS
  
Inhibitor
Name:
BDBM107156
Synonyms:
US8592426, 5
Type:
n/a
Emp. Form.:
C24H19ClF4N4O3
Mol. Mass.:
522.879
SMILES:
Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F |r|
Structure:
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