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Target
Kininogen-1
Ligand
BDBM107189
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
IC50
0.2±n/a nM
Citation
 Aebi, J; Binggeli, A; Hertel, C; Konkar, AA; Kuehne, H; Kuhn, B; Maerki, HP; Wang, H Aryl-benzocycloalkyl amide derivatives US Patent  US8592426 Publication Date 11/26/2013 
Target
Name:
Kininogen-1
Synonyms:
BDK | Bradykinin-1 Receptor | KNG | KNG1 | KNG1_HUMAN
Type:
Enzyme
Mol. Mass.:
71962.11
Organism:
Homo sapiens (Human)
Description:
P01042
Residue:
644
Sequence:
MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS
  
Inhibitor
Name:
BDBM107189
Synonyms:
US8592426, 38
Type:
Small organic molecule
Emp. Form.:
C26H22ClFN6O5
Mol. Mass.:
552.941
SMILES:
COc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Structure:
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