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Target
Prunasin hydrolase
Ligand
BDBM108217
Substrate
n/a
Meas. Tech.
Inhibition Assay Against Commercial Glycosidases
pH
10.6±n/a
Temperature
310.15±n/a K
IC50
79±n/a nM
Comments
extracted
Citation
 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease. Chembiochem 14:1239-47 (2013) [PubMed]  Article 
Target
Name:
Prunasin hydrolase
Synonyms:
β-glucosidase | Prunasin hydrolase
Type:
Protein
Mol. Mass.:
61905.54
Organism:
Prunus dulcis (Almond)
Description:
n/a
Residue:
544
Sequence:
MALQFRSLLLCMVLLLLGFALANTNAARTDPPIVCATLNRTHFDTLFPGFTFGAATAAYQLEGAANIDGRGPSVWDNFTHEHPEKITDGSNGDVAIDQYHRYKEDVAIMKDMGLDAYRFSISWSRLLPNGKLSGGINKKGIEYYNNLTNELLRNGIEPLVTLFHWDVPQALVDEYGGLLSPRIVDDFKAYADLCYKEFGDRVKHWTTLNEPYTISNHGYTIGIHAPGRCSDWYNPKCLGGDSGIEPYLVTHYLLLAHAAAVKLYREKYQAYQNGVIGITVVSHWFEPASESQQDKDAAFQALDFMYGWFMDPLTRGDYPQIMRSILGARLPNFTEEQSKSLSGSYDYIGVNYYSARYASAYPKDYSVTTPPSYLTDVHVNVTTDLNGVPIGPRAASDWLYVYPKGLYDLVLYTKEKYNDPIMYITENGMDEFNNPKLSLEQALNDGNRIDYYYRHLCYLQAAMKEGANVQGYFAWSLLDNFEWSEGYTVRFGINYIDYDNGLERHSKLSTHWFKSFLKRSSISKKKIRRCGNNNGRATKFVYQI
  
Inhibitor
Name:
BDBM108217
Synonyms:
2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 3)
Type:
Small organic molecule
Emp. Form.:
C14H24N2O4
Mol. Mass.:
284.3514
SMILES:
CC(C)(C)CCc1cn2C(CO)C(O)C(O)C(O)c2n1
Structure:
Search PDB for entries with ligand similarity: