Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1 [33-574]
Ligand
BDBM108245
Substrate
n/a
IC50
7.20e+5± 9.0e+4 nM
Citation
 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH. Chembiochem 14:1611-9 (2013) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [33-574]
Synonyms:
FAAH1_RAT | Faah | Faah1 | Fatty-acid amide hydrolase (rFAAH∆TM)
Type:
Protein
Mol. Mass.:
59459.86
Organism:
Rattus norvegicus (Rat)
Description:
97-1722bp
Residue:
542
Sequence:
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP
  
Inhibitor
Name:
BDBM108245
Synonyms:
2‐[3‐(trifluoromethyl)phenyl]acetonitrile (Hit 13)
Type:
Small organic molecule
Emp. Form.:
C9H6F3N
Mol. Mass.:
185.1458
SMILES:
FC(F)(F)c1cccc(CC#N)c1
Structure:
Search PDB for entries with ligand similarity: